Expression of functional melanocortin-4 receptor in the hypothalamic GT1-1 cell line.

@article{Khong2001ExpressionOF,
  title={Expression of functional melanocortin-4 receptor in the hypothalamic GT1-1 cell line.},
  author={Kathy Khong and Stephen E. Kurtz and Ren{\'e}e Sykes and Roger D Cone},
  journal={Neuroendocrinology},
  year={2001},
  volume={74 3},
  pages={193-201}
}
Mutations in the melanocortin-4 receptor (MC4-R) cause obesity in both mice and humans, and the receptor is presumed to have an important role in the regulation of energy homeostasis. The MC4-R is expressed in discrete sets of neurons in the central nervous system, and thus it has been technically difficult to study the regulation of expression and the signaling mechanisms of this receptor. We report here a neuronal cell line that exhibits endogenous functional expression for the MC4-R… CONTINUE READING