Expression of functional chemokine receptors by rat cerebellar neurons.


In this study, we examined chemokine receptor expression and function in rat cerebellar neurons. Calcium imaging experiments demonstrated that a wide variety of chemokines elicited [Ca(2+)](i) transients in acutely isolated and cultured cerebellar Purkinje and granule neurons. In many cases, these chemokine responses were pertussis toxin (PTX) insensitive. In addition, chemokines activated the Ca(2+) and cAMP-dependent transcription factor CREB and the extracellular response kinases ERK1/ERK2. Chemokines increased the survival of Purkinje neurons deprived of their trophic support. Thus, the presence of chemokine receptors and the signaling pathways they activate suggest that chemokines play a role in the control of cerebellar neuron survival and development and may mediate communication between the CNS and the immune system.

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@article{Gillard2002ExpressionOF, title={Expression of functional chemokine receptors by rat cerebellar neurons.}, author={Samantha E. Gillard and Meiling Lu and Rose M Mastracci and Richard J. Miller}, journal={Journal of neuroimmunology}, year={2002}, volume={124 1-2}, pages={16-28} }