Expression of functional chemokine receptors by rat cerebellar neurons.

Abstract

In this study, we examined chemokine receptor expression and function in rat cerebellar neurons. Calcium imaging experiments demonstrated that a wide variety of chemokines elicited [Ca(2+)](i) transients in acutely isolated and cultured cerebellar Purkinje and granule neurons. In many cases, these chemokine responses were pertussis toxin (PTX) insensitive. In addition, chemokines activated the Ca(2+) and cAMP-dependent transcription factor CREB and the extracellular response kinases ERK1/ERK2. Chemokines increased the survival of Purkinje neurons deprived of their trophic support. Thus, the presence of chemokine receptors and the signaling pathways they activate suggest that chemokines play a role in the control of cerebellar neuron survival and development and may mediate communication between the CNS and the immune system.

02040'03'05'07'09'11'13'15'17
Citations per Year

155 Citations

Semantic Scholar estimates that this publication has 155 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Gillard2002ExpressionOF, title={Expression of functional chemokine receptors by rat cerebellar neurons.}, author={Samantha E. Gillard and Meiling Lu and Rose M Mastracci and Richard J. Miller}, journal={Journal of neuroimmunology}, year={2002}, volume={124 1-2}, pages={16-28} }