Expression of functional acetylcholine receptor from cloned cDNAs

@article{Mishina1984ExpressionOF,
  title={Expression of functional acetylcholine receptor from cloned cDNAs},
  author={Masayoshi Mishina and Tomohiro Kurosaki and Takamasa Tobimatsu and Yuuki Morimoto and Masaharu Noda and Tokuo T. Yamamoto and Mineko Terao and J. C. Lindstrom and Tomoyuki Takahashi and Motoy Kuno and Shosaku Numa},
  journal={Nature},
  year={1984},
  volume={307},
  pages={604-608}
}
The cloned cDNAs encoding the four subunits of the Torpedo californica acetylcholine receptor, each carried by a simian virus 40 vector, direct the synthesis of the functional receptor in a combined expression system consisting of COS monkey cells and Xenopus oocytes. Our results suggest that all four subunits are required to elicit a normal nicotinic response to acetylcholine, whereas only the α-subunit is indispensable for α-bungarotoxin binding activity. 

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