Expression of functional RANK on mature rat and human osteoclasts.

  title={Expression of functional RANK on mature rat and human osteoclasts.},
  author={Damian E. Myers and Fiona McL Collier and Cedric Minkin and Hong-gang Wang and Wayne R Holloway and Mary Malakellis and Geoffrey Charles Nicholson},
  journal={FEBS letters},
  volume={463 3},
Although the important roles of RANK/RANKL in osteoclastogenesis have been established, their roles in the regulation of mature osteoclasts remain uncertain. Microisolation has been used to obtain pure populations of rat and human osteoclasts for RT-PCR analysis. RANK and calcitonin receptor mRNA was detected in all the samples whereas OPG and ALP mRNA was… CONTINUE READING