Expression of folate transporters in human placenta and implications for homocysteine metabolism.

@article{Solanky2010ExpressionOF,
  title={Expression of folate transporters in human placenta and implications for homocysteine metabolism.},
  author={Nita Solanky and A Requena Jimenez and Stephen W D'souza and Colin P Sibley and Jocelyn D Glazier},
  journal={Placenta},
  year={2010},
  volume={31 2},
  pages={134-43}
}
Poor folate status during pregnancy can lead to elevated maternal plasma levels of homocysteine (Hcy) with associated pregnancy complications and adverse neonatal outcomes, suggesting placental metabolism of Hcy might be an important determinant in influencing fetal development. The metabolic pathways for Hcy in placenta are not well defined. In this study we examined the gene expression of key enzymes involved in Hcy metabolism in first trimester and term human placenta to determine which… CONTINUE READING