Expression of fatty acid binding proteins 3 and 5 genes in rat pancreatic islets and INS-1E cells: regulation by fatty acids and glucose.

@article{Hyder2010ExpressionOF,
  title={Expression of fatty acid binding proteins 3 and 5 genes in rat pancreatic islets and INS-1E cells: regulation by fatty acids and glucose.},
  author={Ayman Hyder and Marwa Zenhom and Maja Klapper and Julia Herrmann and J{\"u}rgen Schrezenmeir},
  journal={Islets},
  year={2010},
  volume={2 3},
  pages={
          174-84
        }
}
Fatty acids binding proteins (FABPs) are involved in uptake, binding, transport and metabolism of fatty acids (FAs). Although FAs are known to stimulate insulin secretion from pancreatic islets when transiently elevated, while contributing to islet loss of function, lipotoxicity and apoptosis when chronically elevated, almost nothing is known regarding the FABPs in this tissue. The present study aimed at exploring the expression pattern and regulation of FABPs in rat islets and the insulin… CONTINUE READING