Expression of factor H binding protein of meningococcus responds to oxygen limitation through a dedicated FNR-regulated promoter.

@article{Oriente2010ExpressionOF,
  title={Expression of factor H binding protein of meningococcus responds to oxygen limitation through a dedicated FNR-regulated promoter.},
  author={Francesca Oriente and Vincenzo Scarlato and Isabel R Delany},
  journal={Journal of bacteriology},
  year={2010},
  volume={192 3},
  pages={691-701}
}
Factor H binding protein (fHBP) is a surface-exposed lipoprotein in Neisseria meningitidis, which is a component of several investigational vaccines against serogroup B meningococcus (MenB) currently in development. fHBP enables the bacterium to evade complement-mediated killing by binding factor H, a key downregulator of the complement alternative pathway, and, in addition, fHBP is important for meningococcal survival in the presence of the antimicrobial peptide LL-37. In this study, we… CONTINUE READING