Expression of extra domain A fibronectin sequence in vascular smooth muscle cells is phenotype dependent

  title={Expression of extra domain A fibronectin sequence in vascular smooth muscle cells is phenotype dependent},
  author={Marina A. Glukhova and Maria G. Frid and Boris V. Shekhonin and T D Vasilevskaya and Juan Grunwald and Marco Saginati and Victor E. Koteliansky},
  journal={The Journal of Cell Biology},
  pages={357 - 366}
Different fibronectin (FN) variants arise from the single gene transcript alternatively spliced in a tissue-specific manner (Hynes, R. O. 1985. Annu. Rev. Cell Biol. 1:67-90; Owens, R. J., A. R. Kornblihtt, and F. E. Baralle. 1986. Oxf. Surv. Eurcaryotic Genes. 3:141-160). We used mAb IST-9, specific for extra domain A (ED-A) FN sequence, and cDNA probe to ED-A exon to determine whether ED-A is present in FN synthesized by vascular smooth muscle cells (SMCs) and, if so, whether expression of ED… CONTINUE READING


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