Expression of estrogen receptor co-regulators NCoR and PELP1 in epithelial cells and myofibroblasts of colorectal carcinomas: cytoplasmic translocation of NCoR in epithelial cells correlates with worse prognosis

@article{Tzelepi2008ExpressionOE,
  title={Expression of estrogen receptor co-regulators NCoR and PELP1 in epithelial cells and myofibroblasts of colorectal carcinomas: cytoplasmic translocation of NCoR in epithelial cells correlates with worse prognosis},
  author={Vassiliki N Tzelepi and Petros Grivas and Zinovia Maria Kefalopoulou and Haralambos P. Kalofonos and John N. Varakis and Georgia Sotiropoulou-Bonikou},
  journal={Virchows Archiv},
  year={2008},
  volume={454},
  pages={41-53}
}
Proline-, glutamic acid-, and leukine-rich protein (PELP1) is a novel co-regulatory protein that modulates genomic and non genomic actions of estrogen receptors. Nuclear receptor co-repressor (NCoR) represses estrogen-receptor-dependent transcription. PELP1 and NCoR expression was evaluated in tissue sections from 107 formalin-fixed, paraffin-embedded colectomy specimens. Normal mucosa and adenomas were also evaluated in 77 and 29 cases, respectively. PELP1 was expressed in a dot-like pattern… CONTINUE READING

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