Expression of estrogen receptor alpha increases leptin-induced STAT3 activity in breast cancer cells.

@article{Binai2010ExpressionOE,
  title={Expression of estrogen receptor alpha increases leptin-induced STAT3 activity in breast cancer cells.},
  author={Nadine A. Binai and Annette Damert and Gert Carra and Stephan Steckelbroeck and Johannes Loewer and Roswitha L{\"o}wer and Silja Wessler},
  journal={International journal of cancer},
  year={2010},
  volume={127 1},
  pages={55-66}
}
Adipositas correlates with an enhanced risk of developing malignant diseases such as breast cancer, endometrial tumor or prostate carcinoma, but the molecular basis for this is not well understood. Potential mechanisms include increased bioavailability of adipocytokines (e.g. leptin) and steroid hormones. Here, we investigated cross-talk between ERalpha (estrogen receptor alpha) and leptin-induced activation of signal transducer and activator of transcription 3 (STAT3), a transactivator of… CONTINUE READING
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