Expression of epithelial to mesenchymal transition-related markers in lymph node metastases as a surrogate for primary tumor metastatic potential in breast cancer

@inproceedings{Markiewicz2012ExpressionOE,
  title={Expression of epithelial to mesenchymal transition-related markers in lymph node metastases as a surrogate for primary tumor metastatic potential in breast cancer},
  author={Aleksandra Markiewicz and Tomasz Ahrends and Marzena Wełnicka-Jaśkiewicz and Barbara Seroczyńska and Jarosław Skokowski and Janusz Jaśkiewicz and Jolanta Szade and Wojciech Biernat and Anna J Zaczek},
  booktitle={Journal of Translational Medicine},
  year={2012}
}
Breast cancers are phenotypically and genotypically heterogeneous tumors containing multiple cancer cell populations with various metastatic potential. Aggressive tumor cell subpopulations might more easily be captured in lymph nodes metastases (LNM) than in primary tumors (PT). We evaluated mRNA and protein levels of master EMT regulators: TWIST1, SNAIL and SLUG, protein levels of EMT-related markers: E-cadherin, vimentin, and expression of classical breast cancer receptors: HER2, ER and PgR… CONTINUE READING
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