Expression of epithelial sodium channel (ENaC) and CFTR in the human epidermis and epidermal appendages

  title={Expression of epithelial sodium channel (ENaC) and CFTR in the human epidermis and epidermal appendages},
  author={Israel Hanukoglu and V. R. Boggula and Hananya Vaknine and Sachin Sharma and T. Kleyman and A. Hanukoglu},
  journal={Histochemistry and Cell Biology},
  • Israel Hanukoglu, V. R. Boggula, +3 authors A. Hanukoglu
  • Published 2016
  • Biology, Medicine
  • Histochemistry and Cell Biology
  • A major function of the skin is the regulation of body temperature by sweat secretions. Sweat glands secrete water and salt, especially NaCl. Excreted water evaporates, cooling the skin surface, and Na+ ions are reabsorbed by the epithelial sodium channels (ENaC). Mutations in ENaC subunit genes lead to a severe multi-system (systemic) form of pseudohypoaldosteronism (PHA) type I, characterized by salt loss from aldosterone target organs, including sweat glands in the skin. In this study, we… CONTINUE READING
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