Expression of epithelial sodium channel (ENaC) and CFTR in the human epidermis and epidermal appendages

@article{Hanukoglu2016ExpressionOE,
  title={Expression of epithelial sodium channel (ENaC) and CFTR in the human epidermis and epidermal appendages},
  author={Israel Hanukoglu and V. R. Boggula and Hananya Vaknine and Sachin Sharma and T. Kleyman and A. Hanukoglu},
  journal={Histochemistry and Cell Biology},
  year={2016},
  volume={147},
  pages={733-748}
}
  • Israel Hanukoglu, V. R. Boggula, +3 authors A. Hanukoglu
  • Published 2016
  • Biology, Medicine
  • Histochemistry and Cell Biology
    • A major function of the skin is the regulation of body temperature by sweat secretions. Sweat glands secrete water and salt, especially NaCl. Excreted water evaporates, cooling the skin surface, and Na+ ions are reabsorbed by the epithelial sodium channels (ENaC). Mutations in ENaC subunit genes lead to a severe multi-system (systemic) form of pseudohypoaldosteronism (PHA) type I, characterized by salt loss from aldosterone target organs, including sweat glands in the skin. In this study, we… CONTINUE READING
    View on Springer
    zenodo.org
    26 Citations
    Background Citations
    13
    Methods Citations
    1
    Results Citations
    1
    26 Citations
    Citation Type

    Citation Type

    Mapping the sites of localization of epithelial sodium channel (ENaC) and CFTR in segments of the mammalian epididymis
    • 6
    Expression of the epithelial sodium channel (ENaC) in the endometrium – Implications for fertility in a patient with pseudohypoaldosteronism
    • 6
    • PDF
    High‐resolution imaging of the actin cytoskeleton and epithelial sodium channel, CFTR, and aquaporin‐9 localization in the vas deferens
    • 2
    Localization of epithelial sodium channel (ENaC) and CFTR in the germinal epithelium of the testis, Sertoli cells, and spermatozoa
    • 17
    • PDF
    Identification and classification of epithelial cells in nephron segments by actin cytoskeleton patterns
    • 4
    Assembly and Trafficking of the Cystic Fibrosis Transmembrane Conductance Regulator and Associated Proteins
    Cisplatin influences the skin ion transport - An in vitro study.
    Analysis of changes in sodium and chloride ion transport in the skin
    • PDF
    New Insights on the Role of Sodium in the Physiological Regulation of Blood Pressure and Development of Hypertension
    • 2
    • PDF
    Cannabinoid Signaling in the Skin: Therapeutic Potential of the “C(ut)annabinoid” System
    • 43
    • PDF

    References

    SHOWING 1-10 OF 72 REFERENCES
    Epithelial sodium channel in human epidermal keratinocytes: expression of its subunits and relation to sodium transport and differentiation.
    • 76
    • PDF
    The Epithelial Sodium Channel ENaC and its Regulators in the Epidermal Permeability Barrier Function
    • 2
    • PDF
    Epithelial Na+ channel delta subunit mediates acid-induced ATP release in the human skin.
    • 20
    The ENaC channel is required for normal epidermal differentiation.
    • 53
    • PDF
    Epithelial sodium channels (ENaC) are uniformly distributed on motile cilia in the oviduct and the respiratory airways
    • 67
    • PDF
    Epithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseases.
    • 157
    • PDF
    Activation of the epithelial Na+ channel (ENaC) requires CFTR Cl- channel function
    • 241
    The cellular localization of Na(+)/H(+) exchanger 1, cystic fibrosis transmembrane conductance regulator, potassium channel, epithelial sodium channel γ and vacuolar-type H+-ATPase in human eccrine sweat glands.
    • 7
    Activation of the epithelial sodium channel (ENaC) by serine proteases.
    • 183
    Epithelial sodium channels are upregulated during epidermal differentiation.
    • 29