Expression of epithelial cell iron-related genes upon infection by Neisseria meningitidis.

@article{Bonnah2004ExpressionOE,
  title={Expression of epithelial cell iron-related genes upon infection by Neisseria meningitidis.},
  author={Robert A. Bonnah and Martina U. Muckenthaler and Hanqian L. Carlson and Bel{\'e}n Mi{\~n}ana and Caroline A Enns and Matthias W. Hentze and Magdalene So},
  journal={Cellular microbiology},
  year={2004},
  volume={6 5},
  pages={
          473-84
        }
}
Infection by the obligate human pathogens Neisseria meningitidis (MC) and Neisseria gonorrhoeae (GC) reduces the expression of host epithelial cell transferrin receptor 1 (TfR-1) (Bonnah et al., 2000, Cellular Microbiology 2: 207-218). In addition, the rate and pattern of TfR-1 cycling is altered, leading to diminished uptake of Tf-iron by infected host cells. As Tf-iron is important for maintaining iron homeostasis in the eukaryotic cell, these findings raised the possibility that Neisseria… CONTINUE READING

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