Expression of epidermal growth factor receptor mRNA and protein in primary breast carcinomas

  title={Expression of epidermal growth factor receptor mRNA and protein in primary breast carcinomas},
  author={Rosemary A. Walker and Sheila J. Dearing},
  journal={Breast Cancer Research and Treatment},
The expression of epidermal growth factor receptor (EGFR) mRNA and protein has been determined in a group of breast carcinomas and compared to oestrogen and progesterone receptor (ER, PgR) status, as well as pathological features. In situ hybridization using a digoxigenin-labelled oligonucleotide probe was applied to formalin-fixed paraffin-embedded sections, and immunohistochemistry was used to determine EGFR protein. EGFR mRNA was detected in 66% of carcinomas with a third having labelling… CONTINUE READING


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