Expression of epidermal growth factor (EGF)/transforming growth factor-alpha by human lung cancer cells determines their response to EGF receptor tyrosine kinase inhibition in the lungs of mice.

@article{Wu2007ExpressionOE,
  title={Expression of epidermal growth factor (EGF)/transforming growth factor-alpha by human lung cancer cells determines their response to EGF receptor tyrosine kinase inhibition in the lungs of mice.},
  author={Wenjuan Wu and Michael S O'reilly and Robert R. Langley and Rachel Z Tsan and Cheryl H. Baker and Neby Bekele and Xi Tang and Amir Onn and Isaiah J. Fidler and Roy S. Herbst},
  journal={Molecular cancer therapeutics},
  year={2007},
  volume={6 10},
  pages={
          2652-63
        }
}
  • Wenjuan Wu, Michael S O'reilly, +7 authors Roy S. Herbst
  • Published in Molecular cancer therapeutics 2007
  • Medicine, Biology
  • Epidermal growth factor receptor (EGFR) has been extensively targeted in the treatment of non-small cell lung cancer, producing responses in a small number of patients. To study the role of ligand expression in mediating response to EGFR antagonism, we injected NCI-H441 [EGFR and EGF/transforming growth factor-alpha (TGF-alpha) positive] or PC14-PE6 (EGFR positive and EGF/TGF-alpha negative) human lung adenocarcinoma cells into the lungs of nude mice. We randomized the mice to receive treatment… CONTINUE READING

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