Expression of epidermal N-methyl-d-aspartate receptors (NMDAR1) depends on formation of the granular layer—analysis in diseases with parakeratotic cornification

Ionotrope glutamate receptors of the N-methyl-d-aspartate (NMDA) receptor type are expressed on keratinocytes and influence the intracellular calcium concentration. The importance of NMDA receptors in pathophysiological processes in the skin is, however, still unclear. Epidermal distribution patterns of NMDA receptors were investigated in dermatoses with… CONTINUE READING