Expression of ephrin‐A2 in the superior colliculus and EphA5 in the retina following optic nerve section in adult rat

  title={Expression of ephrin‐A2 in the superior colliculus and EphA5 in the retina following optic nerve section in adult rat},
  author={Jennifer Rodger and Kevin A. Lindsey and Simone G. Leaver and Carolyn E. King and Sarah A. Dunlop and Lyn Beazley},
  journal={European Journal of Neuroscience},
The vertebrate retina projects topographically to visual brain centres. In the developing visual system, gradients of ephrins and Eph receptors play a role in defining topography. At maturity, ephrins but not Ephs are downregulated. Here we show that optic nerve section in adult rat differentially regulates the expression of ephrin‐A2 in the superior colliculus (SC) and of EphA5 in the retina. Expression was quantified immunohistochemically; ephrin‐A2 levels were also estimated by… 
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