Expression of enhancing factor gene and its localization in mouse tissues

@article{Mulherkar2004ExpressionOE,
  title={Expression of enhancing factor gene and its localization in mouse tissues},
  author={Rita Mulherkar and Shefali J. Desai and R. S. Rao and A. S. Wagle and Madhav G. Deo},
  journal={Histochemistry},
  year={2004},
  volume={96},
  pages={367-370}
}
SummaryEnhancing factor (EF), a 14 kDa protein, isolated from mouse small intestines, has been reported from this laboratory. Based on our earlier studies EF has been implicated in cell proliferation. Preliminary immunohistochemical studies have shown EF to be localized in the Paneth cells of small intestines. In this paper we report the tissue distribution of EF using conditions optimized for immunohistochemical staining. In addition, the data are supported by northern blot analysis using a… 
Expression of enhancing factor/phospholipase A2 in ICRC mice
TLDR
The molecular characterization of the ICRC mouse with respect to the enhancing factor gene is reported, demonstrating that EF from Balb/c and ICRC intestines are either immunologically identical or closely related to each other although, quantitatively, EF was very low in ICRC mice.
Trace amounts of enhancing factor/phospholipase A2 in mouse peritoneal exudate cells
TLDR
The presence of trace amounts of EF in the peritoneal exudate cells could be a unique mode of transport of growth factor modulator to the site of injury to aid in regeneration/cell proliferation of damaged tissue.
Comparison of the activities of wild type and mutant enhancing factor/mouse secretory phospholipase A2 proteins
TLDR
Deletion mutation analysis of EF cDNA carried out in the laboratory showed that enhancing activity and phospholipase activity are two separate activities that reside in the same molecule.
Expression of enhancing factor/phospholipase A2 in skin results in abnormal epidermis and increased sensitivity to chemical carcinogenesis
Enhancing factor (EF), a growth factor modulator, is the mouse homologue of human secretory group II phospholipase A2. EF exhibits growth-promoting activity in vitro, in the presence of epidermal
Influence of high-calorie (cafeteria) diets on the population of Paneth cells in the small intestine of the rat.
TLDR
The effect of high-carbohydrate (HC) and high-fat (HF) cafeteria diets on the PC population in the small intestine of the adult rat is analyzed and a multifactorial control of PC density is proposed.
The roles of sPLA 2-IIA ( Pla 2 g 2 a ) in cancer of the small and large intestine
TLDR
SPLA2-IIA protects the mucosa from bacterial damage and prevents chronic inflammation and maintains a balance between Wnt, Notch and other key signaling pathways, and promotes apoptosis of cancer cells.
Ontogeny of enhancing factor in mouse intestines and skin
TLDR
This study of the ontogeny of EF shows that the appearance of the protein coincides with the appearing of mature Paneth cells of the small intestines, which means EF is associated with tissues which have a high growth rate.
Expression of secretory phospholipase A2 in colon tumor cells potentiates tumor growth
TLDR
The ability of sPLA2‐IIA to slow tumor cell growth is dependent upon the availability of substrate, and that in some instances sPLA1‐IIASWR may actually enhance tumor growth.
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