Expression of endothelins and their receptors promotes an invasive phenotype of breast tumor cells but is insufficient to induce invasion in benign cells.

@article{Hagemann2005ExpressionOE,
  title={Expression of endothelins and their receptors promotes an invasive phenotype of breast tumor cells but is insufficient to induce invasion in benign cells.},
  author={Thorsten Hagemann and C. Binder and Lutz Binder and Tobias Pukrop and Lorenz H. Truemper and Matthew J. Grimshaw},
  journal={DNA and cell biology},
  year={2005},
  volume={24 11},
  pages={
          766-76
        }
}
There is increased staining of endothelins (ET-1, -2, and -3) and receptors (ET-RA and -RB) in invasive breast tumors compared to nonneoplastic tissue, and ETs stimulate MCF-7 cell invasion in vitro. We analyzed ETstimulation of benign and transformed mammary epithelial cells, and whether expression of ETs is sufficient to induce invasiveness. In breast cancer patient serum, ET-1 was increased in those patients with lymph node metastases compared to those with no lymph node involvement; ETs… CONTINUE READING
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