Expression of endothelin-1 and endothelin-converting enzyme-1 mRNAs and proteins in failing human hearts.

@article{Fukuchi1998ExpressionOE,
  title={Expression of endothelin-1 and endothelin-converting enzyme-1 mRNAs and proteins in failing human hearts.},
  author={Mitsumasa Fukuchi and Adel Giaid},
  journal={Journal of cardiovascular pharmacology},
  year={1998},
  volume={31 Suppl 1},
  pages={S421-3}
}
Accumulating evidence suggests that endogenous endothelin-1 (ET-1) may contribute to the development of heart failure. In this study we determined sites of ET-1 synthesis and production in the failing human myocardium by immunohistochemistry and in situ hybridization for ET-1 and endothelin-converting enzyme-1 (ECE-1). Myocardial tissues were obtained from 19 patients with heart failure and from four noncardiac patients as controls. In both failing and nonfailing hearts, apparent… CONTINUE READING