Expression of endothelial nitric oxide synthase is suppressed in the renal vasculature of angiotensinogen-gene knockout mice

@article{Kihara2005ExpressionOE,
  title={Expression of endothelial nitric oxide synthase is suppressed in the renal vasculature of angiotensinogen-gene knockout mice},
  author={Minoru Kihara and Keiko Sato and Tatsuo Hashimoto and Nozomi Imai and Yoshiyuki Toya and Satoshi Umemura},
  journal={Cell and Tissue Research},
  year={2005},
  volume={323},
  pages={313-320}
}
We have attempted to elucidate the mechanism by which endothelial-type nitric oxide synthase (eNOS) is regulated in the kidney, with special reference to the role of renal hemodynamics and angiotensin II (Ang II). We compared angiotensinogen gene knockout (Atg−/−) mice, which lacked Ang II (resulting in sodium/water depletion and severe hypotension), with wild-type (Atg+/+) mice. Using Western blot analysis and the NADPH diaphorase histochemical reaction, we found that the expression and… CONTINUE READING

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