Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice

@inproceedings{Steffen2017ExpressionOE,
  title={Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice},
  author={Johannes Steffen and Markus Krohn and Christina Schwitlick and Thomas Br{\"u}ning and Kristin Paarmann and Claus U. Pietrzik and Henrik Biverst{\aa}l and Baiba Jansone and Oliver Langer and Jens Pahnke},
  booktitle={Acta neuropathologica communications},
  year={2017}
}
Amyloid-β (Aβ) deposition is one of the hallmarks of the amyloid hypothesis in Alzheimer's disease (AD). Mouse models using APP-transgene overexpression to generate amyloid plaques have shown to model only certain parts of the disease. The extent to which the data from mice can be transferred to man remains controversial. Several studies have shown… CONTINUE READING