Expression of drug-metabolizing enzymes and P-170 glycoprotein in colorectal carcinoma and normal mucosa.

@article{Peters1992ExpressionOD,
  title={Expression of drug-metabolizing enzymes and P-170 glycoprotein in colorectal carcinoma and normal mucosa.},
  author={Wilbert H. M. Peters and Calvin Boon and Hennie M.J. Roelofs and Theo Wobbes and Fokko M. Nagengast and Pierre Kremers},
  journal={Gastroenterology},
  year={1992},
  volume={103 2},
  pages={448-55}
}
Resistance to chemotherapy is a significant problem in the treatment of colorectal carcinomas. To obtain insight into the mechanism of drug resistance, the expression of P-170 glycoprotein and biotransformation enzymes that are potentially able to contribute to drug resistance were investigated in paired samples of normal mucosa and tumors from 24 patients with colorectal cancer. In the tumors, glutathione S-transferase (GST) enzyme activity and content of GST-pi and P-170 glycoprotein were… CONTINUE READING
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