Expression of double-stranded RNA-activated protein kinase in keratinocytes and keratinocytic neoplasia.

@article{Kuyama2003ExpressionOD,
  title={Expression of double-stranded RNA-activated protein kinase in keratinocytes and keratinocytic neoplasia.},
  author={Michiyo Kuyama and Gen Nakanishi and Jir{\^o} Arata and K Iwatsuki and Wataru Fujimoto},
  journal={The Journal of dermatology},
  year={2003},
  volume={30 8},
  pages={579-89}
}
Double-stranded RNA-activated protein kinase (PKR) is a interferon-induced protein initially known for its inhibitory effects on cellular and viral protein synthesis. In recent studies, PKR has been shown to be an important participant in a broad array of cellular processes, including signal transduction, differentiation, apoptosis, cell growth, and tumorigenesis. The expression of PKR in normal human keratinocytes (NHEK) was examined, and its expression in several skin lesions was compared… CONTINUE READING

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PKR was partially detected in atypical cells in non - invasive keratinocytic neoplasia but was completely absent from undifferentiated tumor cells of squamous cell carcinoma .
PKR was partially detected in atypical cells in non - invasive keratinocytic neoplasia but was completely absent from undifferentiated tumor cells of squamous cell carcinoma .
RNAChemical or drug initiates biological processProtein Biosynthesis
Double - stranded RNA - activated protein kinase ( PKR ) is a interferon - induced protein initially known for its inhibitory effects on cellular and viral protein synthesis .
The expression of PKR in normal human keratinocytes ( NHEK ) was examined , and its expression in several skin lesions was compared immunohistochemically with that of proliferating cell nuclear antigen ( PCNA ) .
The expression of PKR in normal human keratinocytes ( NHEK ) was examined , and its expression in several skin lesions was compared immunohistochemically with that of proliferating cell nuclear antigen ( PCNA ) .
The expression of PKR in normal human keratinocytes ( NHEK ) was examined , and its expression in several skin lesions was compared immunohistochemically with that of proliferating cell nuclear antigen ( PCNA ) .
The expression of PKR in normal human keratinocytes ( NHEK ) was examined , and its expression in several skin lesions was compared immunohistochemically with that of proliferating cell nuclear antigen ( PCNA ) .
The expression of PKR in normal human keratinocytes ( NHEK ) was examined , and its expression in several skin lesions was compared immunohistochemically with that of proliferating cell nuclear antigen ( PCNA ) .
The expression of PKR in normal human keratinocytes ( NHEK ) was examined , and its expression in several skin lesions was compared immunohistochemically with that of proliferating cell nuclear antigen ( PCNA ) .
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