Expression of different phosphodiesterase genes in human cavernous smooth muscle.

  title={Expression of different phosphodiesterase genes in human cavernous smooth muscle.},
  author={Andrea K{\"u}the and A Wiedenroth and H J M{\"a}gert and Stefan Uckert and Wolf Georg Forssmann and Christian G Stief and Udo Jonas},
  journal={The Journal of urology},
  volume={165 1},
PURPOSE Knowledge of intracellular signal propagation in smooth muscle tone regulation is of major importance in the understanding of the physiology of penile erection, and the development of new and selective pharmacological agents for the treatment of related disorders. Since phosphodiesterases (PDE) are key enzymes of the signaling pathway, we elucidate their presence and potential functional relevance in human cavernous tissue. MATERIALS AND METHODS To identify PDE messenger RNA in human… CONTINUE READING
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