Expression of different mutant p53 transgenes in neuroblastoma cells leads to different cellular responses to genotoxic agents.


The involvement of p53 as a determinant of chemosensitivity or radiosensitivity is not well understood and is complicated by numerous contradictory reports. Here we have addressed this issue using a series of isogenic clones derived from two neuroblastoma cell lines that express wild-type p53 genes, Nub7 and IMR32. Two different mutant p53 transgenes were… (More)


  • Presentations referencing similar topics