Expression of different isoforms of TGF-beta and the latent TGF-beta binding protein (LTBP) by rat Kupffer cells.

@article{Roth1998ExpressionOD,
  title={Expression of different isoforms of TGF-beta and the latent TGF-beta binding protein (LTBP) by rat Kupffer cells.},
  author={Stina Roth and Wei-yan Gong and Axel M. Gressner},
  journal={Journal of hepatology},
  year={1998},
  volume={29 6},
  pages={915-22}
}
BACKGROUND/AIMS Kupffer cells (liver resident macrophages) make an important contribution to the perpetuation of liver diseases by synthesis and secretion of TGF-beta. In some cell types TGF-beta, is expressed as a large latent complex containing the latent TGF-beta binding protein (LTBP) in addition to the N-terminal TGF-beta precursor (latency associated peptide). This study aimed to identify LTBP expression in rat Kupffer cells. METHODS Cells were isolated from rat liver by collagenase… CONTINUE READING