Expression of delta-aminolevulinate synthase in avian cells: separate genes encode erythroid-specific and nonspecific isozymes.

@article{Riddle1989ExpressionOD,
  title={Expression of delta-aminolevulinate synthase in avian cells: separate genes encode erythroid-specific and nonspecific isozymes.},
  author={R D Riddle and Mika Yamamoto and James Douglas Engel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1989},
  volume={86 3},
  pages={
          792-6
        }
}
A controversy has existed in the literature for the past several years regarding the number of vertebrate genes encoding the mitochondrial protein that initiates the first step in heme biosynthesis, delta-aminolevulinate synthase [ALAS; succinyl-CoA: glycine C-succinyltransferase (decarboxylating), EC 2.3.1.37]. By analysis of chicken ALAS cDNA clones isolated from both liver and erythroid cells, we show that at least two separate genes encode ALAS mRNAs. These experiments show that (i) two… CONTINUE READING

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