Expression of decorin and biglycan by rabbit articular chondrocytes. Effects of cytokines and phenotypic modulation.

@article{DemoorFossard1998ExpressionOD,
  title={Expression of decorin and biglycan by rabbit articular chondrocytes. Effects of cytokines and phenotypic modulation.},
  author={Magali Demoor-Fossard and Françoise R{\'e}din{\'i} and Martine Boittin and J. P. Pujol},
  journal={Biochimica et biophysica acta},
  year={1998},
  volume={1398 2},
  pages={179-91}
}
In this study, the levels of mRNAs coding for aggrecan, decorin and biglycan in rabbit articular chondrocytes were investigated, using both monolayer and 3D-alginate cultures treated with TGF-beta 1 and IL-1 beta. The cells were shown to express higher amounts of proteoglycan messages, specially the aggrecan, in gels than in monolayers. TGF-beta 1 increased aggrecan mRNA in both systems, whereas biglycan message was elevated only in alginate. It markedly decreased decorin expression in… CONTINUE READING

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