Expression of decorin, biglycan, and collagen type I in human renal fibrosing disease.

@article{Stokes2000ExpressionOD,
  title={Expression of decorin, biglycan, and collagen type I in human renal fibrosing disease.},
  author={Michael B Stokes and Sebastian Holler and Yan Cui and Kelly L. Hudkins and Frank Eitner and Agnes Fogo and Charles Edward Alpers},
  journal={Kidney international},
  year={2000},
  volume={57 2},
  pages={
          487-98
        }
}
BACKGROUND The extracellular matrix proteoglycans decorin and biglycan may have a pathogenic role in renal fibrosing disease via regulation of the activity of growth factors, such as transforming growth factor-beta, and effects on collagen type I fibrillogenesis. The expression of decorin and biglycan in human glomerular diseases characterized by mesangial sclerosis is unknown. METHODS Decorin, biglycan, and collagen type I were localized immunohistochemically in human renal biopsy cases of… CONTINUE READING

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