Expression of death-associated protein kinase during tumour progression of human renal cell carcinomas: hypermethylation-independent mechanisms of inactivation.

@article{Wethkamp2006ExpressionOD,
  title={Expression of death-associated protein kinase during tumour progression of human renal cell carcinomas: hypermethylation-independent mechanisms of inactivation.},
  author={Nils Wethkamp and Uwe Ramp and Helene Geddert and Wolfgang A. Schulz and Andrea R. Florl and Christoph Viktor Suschek and Mohamed L. Hassan and Helmut Erich Gabbert and Csaba Mahotka},
  journal={European journal of cancer},
  year={2006},
  volume={42 2},
  pages={264-74}
}
Death-associated protein kinase (DAPK) is a pro-apoptotic Ca(2+)/calmodulin-dependent serine/threonine kinase that is widely expressed in tissues but kept silent in growing cells. Downregulation of DAPK transcription by CpG methylation has been demonstrated in a variety of tumours, providing a selective growth advantage during tumour progression. As the in vivo expression of DAPK in human renal cell carcinomas (RCCs) has not previously been analysed, 72 RCCs were investigated using semi… CONTINUE READING