Expression of cytochrome P4502E1 in human liver: assessment by mRNA, genotype and phenotype.

@article{Powell1998ExpressionOC,
  title={Expression of cytochrome P4502E1 in human liver: assessment by mRNA, genotype and phenotype.},
  author={Harley Powell and Neil R. Kitteringham and Munir Pirmohamed and Dennis A. Smith and Brian Kevin Park},
  journal={Pharmacogenetics},
  year={1998},
  volume={8 5},
  pages={411-21}
}
Cytochrome P4502E1 (CYP2E1) is constitutively expressed in human liver and is responsible for the metabolic bioactivation of a wide variety of xenobiotics, including a number of protoxins and procarcinogens. CYP2E1 expression is regulated at several levels including pre-transcriptional, transcriptional and post-transcriptional levels, and any variation in enzyme concentration and hence activity may represent increased risk of toxicity or carcinogenicity. We have investigated variability in the… CONTINUE READING

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