Expression of cyclooxygenase-2 promotes the release of matrix metalloproteinase-2 and -9 in fetal rat hepatocytes.

@article{Callejas2001ExpressionOC,
  title={Expression of cyclooxygenase-2 promotes the release of matrix metalloproteinase-2 and -9 in fetal rat hepatocytes.},
  author={Nuria A. Callejas and M. Sanchez Casado and Mar{\'i}a Jos{\'e} M D{\'i}az-Guerra and Lisardo Bosc{\'a} and Paloma Mart{\'i}n-Sanz},
  journal={Hepatology},
  year={2001},
  volume={33 4},
  pages={860-7}
}
Treatment of primary cultures of fetal hepatocytes with proinflammatory cytokines, lipopolysaccharide (LPS), and hepatocyte growth factor promoted the expression of cyclooxygenase-2 (COX-2) and the synthesis of high amounts of prostaglandins (PGs). Under these conditions, the active forms of the matrix metalloproteinases-2 and -9 (MMPs) were released to the extracellular medium. This process was inhibited when the synthesis of PGs was suppressed pharmacologically with COX-2 inhibitors. Addition… CONTINUE READING
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