Expression of cyclooxygenase-2 parallels expression of interleukin-1beta, interleukin-6 and NF-kappaB in human colorectal cancer.

@article{Maihfner2003ExpressionOC,
  title={Expression of cyclooxygenase-2 parallels expression of interleukin-1beta, interleukin-6 and NF-kappaB in human colorectal cancer.},
  author={Christian Maih{\"o}fner and Michalis Panayiotou Charalambous and Upinder Bhambra and Tracy J Lightfoot and Gerd 7 Geisslinger and Nigel J. Gooderham},
  journal={Carcinogenesis},
  year={2003},
  volume={24 4},
  pages={665-71}
}
Elevated expression of cyclooxygenase-2 (COX-2), the inducible isoform of prostaglandin H synthase, has been found in several human cancers, including colorectal cancer (CRC). This appears as a rationale for the chemopreventive effects of non-steroidal anti-inflammatory drugs in CRC. However, the reason for COX-2 overexpression is not fully understood. In cell culture experiments, COX-2 can be induced by proinflammatory cytokines, such as interleukin (IL)-1beta and IL-6. A crucial step in this… CONTINUE READING

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Mentioned Connections BETA
A crucial step in this signalling pathway is thought to be activation of transcription factor NF - kappaB. Based on these findings , we hypothesized an association between COX-2 overexpression and expression of IL-1beta , IL-6 and the NF - kappaB subunit p65 in human CRC .
TRANSCRIPTION FACTORIs biochemical function of gene productNF-kappa B
A crucial step in this signalling pathway is thought to be activation of transcription factor NF - kappaB. Based on these findings , we hypothesized an association between COX-2 overexpression and expression of IL-1beta , IL-6 and the NF - kappaB subunit p65 in human CRC .
NF-kappa BGene product plays role in biological processSignal Transduction
A crucial step in this signalling pathway is thought to be activation of transcription factor NF - kappaB. Based on these findings , we hypothesized an association between COX-2 overexpression and expression of IL-1beta , IL-6 and the NF - kappaB subunit p65 in human CRC .
A crucial step in this signalling pathway is thought to be activation of transcription factor NF - kappaB. Based on these findings , we hypothesized an association between COX-2 overexpression and expression of IL-1beta , IL-6 and the NF - kappaB subunit p65 in human CRC .
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