Expression of cyclooxygenase-2 mRNA after global ischemia is regulated by AMPA receptors and glucocorticoids.

@article{Koistinaho1999ExpressionOC,
  title={Expression of cyclooxygenase-2 mRNA after global ischemia is regulated by AMPA receptors and glucocorticoids.},
  author={Jari Koistinaho and Susanna Koponen and Pak Hoo Chan},
  journal={Stroke},
  year={1999},
  volume={30 9},
  pages={1900-5; discussion 1905-6}
}
BACKGROUND AND PURPOSE Cyclooxygenase-2 (COX-2) is implicated in ischemic neuronal death. In focal ischemia, its mRNA induction is mediated through N-methyl-D-aspartic acid (NMDA) receptors and phospholipase A(2). Because mechanisms of neuronal death involving COX-2 in global ischemia are unclear, we studied the time course and regulation of COX-2 expression in rat brain global ischemia. METHODS Global ischemia was induced by a 4-vessel occlusion method. COX-2 mRNA levels were demonstrated… CONTINUE READING

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