Expression of cyclooxygenase-2 in prostate carcinoma.

  title={Expression of cyclooxygenase-2 in prostate carcinoma.},
  author={Rikio Yoshimura and Hajime Sano and Chikayoshi Masuda and Masafumi Kawamura and Yasunori Tsubouchi and Jamel Chargui and Norio Yoshimura and Tim Hla and Seiji Wada},
  volume={89 3},
BACKGROUND Nonsteroidal antiinflammatory drugs inhibiting cyclooxygenase (COX) enzyme activity in both its constitutive (COX-1) and inducible (COX-2) isoforms were shown also to inhibit the development of colon carcinoma in animal models. COX-2 is an inducer of angiogenesis of new blood vessels. The expression of COX-1 and COX-2 in prostate tissues from patients with prostate carcinoma was investigated using reverse transcriptase-polymerase chain reaction (RT-PCR) and immunohistochemistry… CONTINUE READING