Expression of cyclooxygenase 2 in human malignant melanoma.

  title={Expression of cyclooxygenase 2 in human malignant melanoma.},
  author={Carsten Denkert and Martin K{\"o}bel and Sven Berger and Antje Siegert and Anja Leclere and Uwe Trefzer and Steffen Hauptmann},
  journal={Cancer research},
  volume={61 1},
Cyclooxygenase (COX)-2 is an inducible enzyme involved in production of prostaglandins in inflammatory processes. There is now increasing evidence that a constitutive expression of COX-2 plays a role in development and progression of malignant epithelial tumors. In the present study we investigated expression and function of COX-2 in malignant melanoma. Expression of COX-2 was determined by immunohistochemistry in 28 cases of primary skin melanoma and 4 benign nevi. We show that COX-2 was… CONTINUE READING