Expression of cyclooxygenase-1 and 2 in naturally-occurring canine cancer.

  title={Expression of cyclooxygenase-1 and 2 in naturally-occurring canine cancer.},
  author={Sulma Ibrahim Mohammed and Kanwar Nasir M. Khan and Rani S. Sellers and Michael G. Hayek and D B Denicola and Lei Wu and Patty L. Bonney and Deborah W Knapp},
  journal={Prostaglandins, leukotrienes, and essential fatty acids},
  volume={70 5},
The purpose of this work was to determine cox-1 and cox-2 expression by immunohistochemistry in forms of naturally occurring canine cancer in order to identify animal systems for pre-clinical evaluation of cox inhibitors and cox-2 inhibitors in cancer. Canine lymphoma (LSA), prostatic carcinoma (PCA), osteosarcoma (OSA), oral melanoma (MEL), oral squamous cell carcinoma (SCC), oral fibrosarcoma (FSA), mammary carcinoma (MCA), and normal tissues were included. Cox-2 was expressed in epithelial… CONTINUE READING


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Cyclooxygenase-2 expression in animal cancers.

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