Expression of cyclo-oxygenase types-1 and -2 in human fetal membranes throughout pregnancy.

@article{Slater1999ExpressionOC,
  title={Expression of cyclo-oxygenase types-1 and -2 in human fetal membranes throughout pregnancy.},
  author={D. M. Slater and William Dennes and Robert John Sawdy and Victoria Allport and Phillip R. Bennett},
  journal={Journal of molecular endocrinology},
  year={1999},
  volume={22 2},
  pages={125-30}
}
Human labour is associated with increased prostaglandin synthesis within the fetal membranes. We have studied the expression of the two isoforms of the central prostaglandin synthetic enzyme, cyclo-oxygenase (COX-1 and COX-2), in human fetal membranes throughout pregnancy, at mRNA, protein and activity levels. COX-1 mRNA expression was low in human amnion and chorion-decidua and did not change with gestational age. COX-2 mRNA expression in fetal membranes increased with gestational age, with… CONTINUE READING