Expression of cyclo-oxygenase-2 in human airway smooth muscle is associated with profound reductions in cell growth.

@article{Belvisi1998ExpressionOC,
  title={Expression of cyclo-oxygenase-2 in human airway smooth muscle is associated with profound reductions in cell growth.},
  author={Maria G Belvisi and Mark A. Saunders and M Yacoub and Jane A Mitchell},
  journal={British journal of pharmacology},
  year={1998},
  volume={125 5},
  pages={1102-8}
}
1. It is now accepted that uncontrolled proliferation of human airway smooth muscle (HASM) cells contributes, in many cases, to the chronic stages of asthma. However, the physiological and pathophysiological processes regulating cell growth and division in the airway are not clear. We have recently shown that the immediate early gene, cyclo-oxygenase-2, is induced by cytokines in HASM cells. Since cyclo-oxygenase metabolites, such as prostaglandin (PG) E2 have been shown to modulate HASM cell… CONTINUE READING
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