Expression of cyclin D1 in parathyroid carcinomas, adenomas, and hyperplasias: a paraffin immunohistochemical study.

@article{Vasef1999ExpressionOC,
  title={Expression of cyclin D1 in parathyroid carcinomas, adenomas, and hyperplasias: a paraffin immunohistochemical study.},
  author={Mohammad A. Vasef and Russell K. Brynes and Matthias Sturm and Christine Bromley and Robert A Robinson},
  journal={Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc},
  year={1999},
  volume={12 4},
  pages={412-6}
}
In this study, we assessed the frequency of cyclin D1 protein expression in normal and neoplastic parathyroid tissue (10 parathyroid carcinomas, 28 adenomas, 18 hyperplasias, and 32 normal parathyroid glands) with use of a monoclonal anticyclin D1 antibody and a heat-induced epitope retrieval method. Overexpression of cyclin D1 was identified in 10 (91%) of 11 biopsy specimens from 10 patients with parathyroid carcinomas and in 11 (39%) of 28 parathyroid adenomas. In addition, 11 (61%) of 18… CONTINUE READING

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