Expression of cyclin D1 and GSK-3beta and their predictive value of prognosis in squamous cell carcinomas of the tongue.

@article{Goto2002ExpressionOC,
  title={Expression of cyclin D1 and GSK-3beta and their predictive value of prognosis in squamous cell carcinomas of the tongue.},
  author={Hideo Goto and Katsunori Kawano and Iwao Kobayashi and Hironori Sakai and Satoru Yanagisawa},
  journal={Oral oncology},
  year={2002},
  volume={38 6},
  pages={549-56}
}
The status of cyclin D1 and glycogen synthase kinase 3beta (GSK-3beta) was investigated in 41 patients with T1 and T2 squamous cell carcinomas (SCCs) of the tongue. Out of the 41 SCCs, 27 (65.9%) showed overexpression of cyclin D1 in comparison with normal lingual epithelia by an immunohistochemical method. Cyclin D1 gene amplification was detected in only… CONTINUE READING