Expression of cyclin D1, cyclin E, cdk4 and loss of heterozygosity of 8p, 13q, 17p in hepatocellular carcinoma: comparison study of childhood and adult hepatocellular carcinoma.

@article{Kim2000ExpressionOC,
  title={Expression of cyclin D1, cyclin E, cdk4 and loss of heterozygosity of 8p, 13q, 17p in hepatocellular carcinoma: comparison study of childhood and adult hepatocellular carcinoma.},
  author={Heui-Soo Kim and Min Jong Lee and Mee-Ran Kim and I. P. Chung and Yong Man Kim and Ja Young J Lee and Ja June Jang},
  journal={Liver},
  year={2000},
  volume={20 2},
  pages={173-8}
}
AIMS/BACKGROUND In hepatitis B virus-related hepatocellular carcinoma (HCC), at least 20-40 years of continuous necro-inflammation is necessary for the hepato-carcinogenesis to occur. However, HCC in childhood shows an unusually short latent period and rapid progression. In our previous report, mutation of c-met was found only in childhood HCC, but not in adult HCC. In order to determine the specific biological tumorous features of childhood HCC, a comparison study of childhood and adult HCC… CONTINUE READING
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