Expression of cyclin B1 in the metaplasia-dysplasia-carcinoma sequence of Barrett esophagus.

@article{Geddert2002ExpressionOC,
  title={Expression of cyclin B1 in the metaplasia-dysplasia-carcinoma sequence of Barrett esophagus.},
  author={Helene Geddert and Hans J{\"o}rg Heep and Helmut Erich Gabbert and Mario Sarbia},
  journal={Cancer},
  year={2002},
  volume={94 1},
  pages={
          212-8
        }
}
BACKGROUND It is known that proliferation is deregulated progressively during carcinogenesis in Barrett esophagus (BE). Cyclin B1 is a key protein for the regulation of G2-M-phase transition during the cell cycle and is essential for initiation of mitosis. METHODS Using immunohistochemistry, samples of Barrett metaplastic specialized epithelium (SE; n = 36 samples), low-grade dysplasia (LGD; n = 25 samples), high-grade dysplasia (HGD; n = 25 samples), and invasive adenocarcinoma (CA; n = 46… CONTINUE READING
BETA

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