Expression of cyclin A and D proteins in prostate cancer and their relation to clinopathological variables and patient survival.

@article{Aaltomaa1999ExpressionOC,
  title={Expression of cyclin A and D proteins in prostate cancer and their relation to clinopathological variables and patient survival.},
  author={Sirpa Aaltomaa and Matti J. Eskelinen and Pertti Lipponen},
  journal={The Prostate},
  year={1999},
  volume={38 3},
  pages={
          175-82
        }
}
BACKGROUND Cell proliferation and its regulation are important determinants of the prognosis of prostate cancer patients. Cyclins are important regulators of cell proliferation in human cancer, but their prognostic value has not been previously analyzed in prostate cancer. METHODS The immunohistochemical expression and prognostic value of cyclins A and D were studied in prostate cancer in a cohort of 213 patients followed-up for a mean of 12 years. RESULTS The expression of cyclin A was… CONTINUE READING

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