Expression of cross-tolerance to a wide range of conditions in a human lung cancer cell line after adaptation to nitric oxide.

Abstract

Previously, we have shown that A549, a human lung adenocarcinoma, can be adapted to nitric oxide (NO●). NO● is a nitrogen-based free radical that is synthesized by a family of enzymes known as nitric oxide synthases. NO● has been shown to be overexpressed in patient populations of different cancers. In addition, it has been observed that patients who… (More)
DOI: 10.1177/1010428317723778

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