Expression of costimulatory molecules in human leukemias.

  title={Expression of costimulatory molecules in human leukemias.},
  author={Noriko Hirano and Takayuki Takahashi and Shigeki Ohtake and Kunitake Hirashima and Nobuhiko Emi and Kenji Saito and Manae Hirano and Katsuaki Shinohara and M Takeuchi and Fumitoshi Taketazu and Saburo Tsunoda and Michinori Ogura and Mitsuhiro Omine and Takeshi Saito and Yoshio Yazaki and Ryuzo Ueda and Hisamaru Hirai},
  volume={10 7},
In order to determine the indication of B7 (B7-1 and B7-2) molecules-mediated immuno-gene therapy for human leukemias, we investigated 94 human leukemic samples for the expression of MHC molecules required for tumor antigen-specific signals and of B7-1, B7-2, and ICAM-1 molecules required for non-specific costimulatory signals. All samples were strongly positive for MHC class I and 84% for class II antigen. B7-1, B7-2 and ICAM-1 were expressed in 5%, 22% and 16% of the total cases, respectively… CONTINUE READING
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