• Biology, Medicine
  • Published in
    Laboratory investigation; a…
    1997

Expression of costimulatory molecules B7-1 and B7-2 in macrophages and granulomas of Crohn's disease: demonstration of cell-to-cell contact with T lymphocytes.

@article{Hara1997ExpressionOC,
  title={Expression of costimulatory molecules B7-1 and B7-2 in macrophages and granulomas of Crohn's disease: demonstration of cell-to-cell contact with T lymphocytes.},
  author={J Hara and Hiroshi Ohtani and Takayuki Matsumoto and S Nakamura and A Kitano and Tetsuo Arakawa and Hiroshi Nagura and Kanna Kobayashi},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  year={1997},
  volume={77 2},
  pages={
          175-84
        }
}
The pathogenesis of Crohn's disease, an intractable inflammatory disease, involves impaired and/or excessive activation of mucosal macrophages and T lymphocytes. B7-1 (CD80) and B7-2 (CD86) molecules are costimulatory molecules that are indispensable to T-cell activation by antigen-presenting cells. To elucidate the roles and characteristics of these antigen-presenting cells in Crohn's disease, in situ localization of B7-1 and B7-2 (in relation to the distribution of T cells) was clarified by… CONTINUE READING

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Type 1 T-helper cell predominance in granulomas of Crohn's disease

  • American Journal of Gastroenterology
  • 1999
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