Expression of corticotropin-releasing factor in inflamed tissue is required for intrinsic peripheral opioid analgesia.

@article{Schafer1996ExpressionOC,
  title={Expression of corticotropin-releasing factor in inflamed tissue is required for intrinsic peripheral opioid analgesia.},
  author={Michael W Schafer and Shaaban A Mousa and Qiuyu Zhang and Lisa Carter and Christoph Stein},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 12},
  pages={6096-100}
}
Immune cell-derived opioid peptides can activate opioid receptors on peripheral sensory nerves to inhibit inflammatory pain. The intrinsic mechanisms triggering this neuroimmune interaction are unknown. This study investigates the involvement of endogenous corticotropin-releasing factor (CRF) and interleukin-1beta (IL-1). A specific stress paradigm, cold water swim (CWS), produces potent opioid receptor-specific antinociception in inflamed paws of rats. This effect is dose-dependently… CONTINUE READING
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