Expression of copper-responsive genes in HepG2 cells

  title={Expression of copper-responsive genes in HepG2 cells},
  author={Min Ok Song and Jonathan H. Freedman},
  journal={Molecular and Cellular Biochemistry},
The hypothesis that copper modulates the activity of intracellular signal transduction pathways to affect transcription, which ultimately disrupts normal development was investigated. Preliminary analysis of transcriptomes from HepG2 cells exposed to copper for 4 and 24 h identified 19 and 7 up-regulated genes (twofold; p ≤ 0.05), respectively. Among the up-regulated genes, several have been previously reported to be responsive to metals or oxidative stress. Differentially expressed genes were… CONTINUE READING
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